Precon2 OnDemand: Physiology of the Weight Reduced State: From Mechanisms to Clinical Application
Description: Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations occurring in the post-weight loss setting, including neuroendocrine-mediated changes in appetite/satiety and reduction of energy expenditure. Following weight loss, peripheral and central mechanisms respond in a way similar to starvation by conveying a sense that energy reserves have dwindled, activating a strong counter-response to increase caloric intake. Moreover, metabolic rate often drops, further compounding the propensity for weight rebound. Evidence suggests these counter-regulatory adaptations may be permanent. Although research is ongoing in this area, early clues have provided valuable insight into clinical management strategies to help patients avoid weight regain. This session will review the current state of knowledge regarding mechanisms of weight regain, identify avenues of further investigation, as well as provide evidence-based clinical strategies to enhance long-term weight loss maintenance in patients with obesity. 
Keyword: Energy Balance: Weight Gain/Regain; Energy Balance: Weight Loss/Maintenance; Treatment: Clinical Practice
Track: Sub-track: Bariatric Surgery and Devices; Sub-track: Nutrition; Sub-track: Obesity Medicine Exam Prep; Track 1: Metabolism and Integrative Physiology; Track 2: Neuroscience; Track 3: Interventional and Clinical Studies; Track 5: Clinical/Professional Practice
Name Role Presentation
Michael Rosenbaum, MD CME Session Speaker The Physiology of the Weight Reduced State: Factors Opposing Weight Loss Maintenance
Michael Rosenbaum, MD CME Session Speaker Q&A
Lee M. Kaplan, MD, PhD, FTOS CME Session Speaker Gut-Brain Biology in Regulation of Food Intake
Lee M. Kaplan, MD, PhD, FTOS CME Session Speaker Q&A
Eric Ravussin, PhD, FTOS CME Session Speaker Metabolic Adaptations in the Weight Reduced State
Eric Ravussin, PhD, FTOS CME Session Speaker Q&A
Beverly G. Tchang, MD, DABOM CME Session Speaker Weight Loss Maintenance with Medical and Surgical Treatments
Beverly G. Tchang, MD, DABOM CME Session Speaker Q&A
Eric Ravussin, PhD, FTOS CME Session Speaker Panel Q&A
Beverly G. Tchang, MD, DABOM CME Session Speaker Panel Q&A
Lee M. Kaplan, MD, PhD, FTOS CME Session Speaker Panel Q&A
Michael Rosenbaum, MD CME Session Speaker Panel Q&A
Learning Objectives:
1. Review the physiological mechanisms that oppose weight loss maintenance.
2. Identify important pathways in the gut-brain axis involved in promoting weight regain.
3. Describe the changes in energy expenditure in the post weight loss setting.
4. Implement clinical treatment recommendations to help patients maintain weight loss over the long-term.